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subacute combined degeneration of spinal cord
Subacute combined degeneration of spinal cord, also known as Lichtheim's disease,〔L. Lichtheim. Zur Kenntnis der perniciösen Anämie. Verhandlungen des Deutschen Kongress für innere Medizin, 1889, 6: 84-96. 42: 1887.〕 refers to degeneration of the posterior and lateral columns of the spinal cord as a result of vitamin B12 deficiency (most common), vitamin E deficiency, and copper deficiency.〔Kumar N, Gross JB Jr, Ahlskog JE. Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration. Neurology. 2004 Jul 13;63(1):33-9.〕 It is usually associated with pernicious anemia.
==Etiologies==
This condition can be due to a dietary deficiency of B12, malabsorption of B12 in the terminal ileum, lack of intrinsic factor secreted from gastric parietal cells, low gastric pH inhibiting attachment of intrinsic factor to ileal receptors.
Vitamin E deficiency, which is associated with malabsorption disorders such as cystic fibrosis and Bassen-Kornzweig syndrome, can cause a similar presentation due to the degeneration of the dorsal columns.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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